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KMID : 0941819950050020071
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Korean Journal of Clinical Pharmacy
1995 Volume.5 No. 2 p.71 ~ p.74
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High Performance Liquid Chromatographic Assay of Non-steroidal Anti-inframmatory Drugs in Plasma
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Abstract
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A high performance liquid chromatographic method has been developed for the simultaneous analysis of non-steroidal anti-inflammatory drugs in plasma. The simultaneous determination of ibuprofen, fenoprofen and ketoprofen is performed by RP-HPLC with UV detection. The chromatographic system consisted of Spherisorb octyl column(5{mu}m) ; the mobile phase was acetonitrile;-;0.5% phosphoric acid(55 : 45, v/v) and the detection wavelength was 230nm. Tolmetin was employed as an internal standard. The method described is rapid and simple with sensitivity limits of 2.0{mu}g/ml ibuprofen, 0.5{mu}g/ml fenoprofen and 0.3{mu}g/ml ketoprofen and is suitable for routine clinical and pharmacokinetic studies.
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KEYWORD
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